Epidemiology of Rickettsial Infection in the Municipality of Uramita, Colombia

• Published in: The American journal of tropical medicine and hygiene Vol. 105; no. 4; pp. 1013 - 1023
• Main Authors: Quintero-Vélez, Juan C, Cienfuegos-Gallet, Astrid V, Quintero, Lisardo Osorio, Úsuga, Andrés F, Cifuentes, Sebastian, Solari, Sergio, Rodas, Juan D, Diaz, Francisco J, Rojas, Carlos A
• Format: Journal Article
• Language: English
• Published: United States Institute of Tropical Medicine 01.10.2021; The American Society of Tropical Medicine and Hygiene
• Subjects: Adult; Animals; Animals, Wild; Arachnids; Colombia - epidemiology; Dogs; Epidemiology; Female; Housing; Housing conditions; Humans; Male; Middle Aged; Opossums; Prospective Studies; Rickettsia Infections - epidemiology; Rickettsia Infections - microbiology; Rickettsia Infections - veterinary; Seroepidemiologic Studies; Serology; Tick Infestations - epidemiology; Tick Infestations - parasitology; Ticks; Young Adult; Colombia
• ISSN: 0002-9637; 1476-1645
• DOI: 10.4269/ajtmh.20-0104

This study aimed to analyze epidemiological indicators related to seroprevalent and seroincident cases of spotted fever group rickettsiae (SFGR) and to identify housing conditions related to tick infestation. A prospective study (2016-2018) was conducted to examine rickettsial seropositivity in humans, domestic animals, and wild mammals in the municipality of Uramita, Antioquia, Colombia, where a previous Rickettsia rickettsii outbreak was reported from 2014 to 2015. The seroprevalence and its associated factors were estimated at baseline, and the seroincidence and its risk factors for humans were estimated 20 months later. A cross-sectional analysis was performed to evaluate the housing conditions linked to tick infestation. The SFGR seroprevalence was 26.70% (95% confidence interval [CI], 20.79-31.37), and the factors associated with SFGR seropositivity were male sex (adjusted prevalence ratio [PRa], 1.67; 95% CI, 1.19-2.32), age (evaluated in 5-year increments) (PRa, 1.05; 95% CI, 1.01-1.09), and household proximity (PRascattered vs. very near=3.87; 95% CI, 1.12-8.66). The overall seroincidence was 7.40% (95% CI, 4.71-11.06), and the factors associated with SFGR seroincident cases were the presence of wild animals (adjusted relative risk [RRa], 2.46; 95% CI, 1.06-4.72) and the presence of trees in the peri-domiciliary area (RRa, 0.47; 95% CI, 0.23-0.94). The prevalence of house tick infestation was 27.81% (95% CI, 21.93-34.80), and the factors associated with infestation were dirt floors (PRa, 5.88; 95% CI, 2.28-10.31), fiber cement roofs (PRa, 1.76; 95% CI, 1.07-2.83), and the presence of canines in peri-domiciliary or intra-domiciliary areas (PRa, 5.05; 95% CI, 3.31-7.19). Seropositivity rates for canines and opossums were 35.62% (26/73) and 100% (6/6), respectively. Identification of these factors will help to implement efficient surveillance programs in Colombia.