Phosphonoxins: Rational design and discovery of a potent nucleotide anti- Giardia agent

• Published in: Bioorganic & medicinal chemistry letters Vol. 17; no. 10; pp. 2811 - 2816
• Main Authors: Suk, Dae-Hwan, Rejman, Dominik, Dykstra, Christine C., Pohl, Radek, Pankiewicz, Krzysztof W., Patterson, Steven E.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15.05.2007; Elsevier
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; Biological and medical sciences; Cyst wall synthase; Drug Design; Encystation; Giardia; Giardia - drug effects; Humans; Medical sciences; Molecular Structure; Nucleotide; Nucleotides - chemistry; Nucleotides - pharmacology; Organophosphonates - chemistry; Organophosphonates - pharmacology; Pharmacology. Drug treatments; Structure-Activity Relationship; Nucleotide; Giardia; Encystation; Cyst wall synthase; Protozoa; Aminoalcohol; Diplomonadida; Organic phosphonate; In vitro; Phosphorus Organic compounds; Antiprotozoal agent; Encystment; Structure activity relation; Parasiticide; Inhibition; Chemical synthesis; Pyrimidine nucleotide; Ribonucleotide
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2007.02.063

Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophocoite growth has been identified. Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.