Circulating microRNAs in patients with non-alcoholic fatty liver disease

AIM: To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease(NAFLD). METHODS: Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The rela-tive expressions of miR-197, miR-146 b, miR-10 b,...

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Published inWorld journal of hepatology Vol. 6; no. 8; pp. 613 - 620
Main Authors Celikbilek, Mehmet, Baskol, Mevlut, Taheri, Serpil, Deniz, Kemal, Dogan, Serkan, Zararsiz, Gokmen, Gursoy, Sebnem, Guven, Kadri, Ozbakır, Omer, Dundar, Munis, Yucesoy, Mehmet
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 27.08.2014
Subjects
disease
fatty
liver
markers
MicroRNA
Nonalcoholic
Noninvasive
Original
Serum
steatohepatitis
Serum markers
Nonalcoholic fatty liver disease
MicroRNA
Nonalcoholic steatohepatitis
Noninvasive
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Summary:AIM: To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease(NAFLD). METHODS: Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The rela-tive expressions of miR-197, miR-146 b, miR-10 b, miR-181d, miR-34 a, miR-122, miR-99 a and miR-29 a were analyzed using real-time polymerase chain reaction. RESULTS: Serum levels of miR-181 d, miR-99 a, miR-197 and miR-146 b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum lev-els of miR-197 and miR-10 b were inversely correlated with degree of inflammation and miR-181 d and miR-99 a were inversely correlated with serum gamma glu-tamyl transferase levels in non-alcoholic steatohepatitis patients. CONCLUSION: NAFLD is associated with altered se-rum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD.
Bibliography:Mehmet Celikbilek;Mevlut Baskol;Serpil Taheri;Kemal Deniz;Serkan Dogan;Gokmen Zarars?z;Sebnem Gursoy;Kadri Guven;Omer Ozbak?r;Munis Dundar;Mehmet Yucesoy;Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey;Department of Medical Genetics, Erciyes University, Medical School, 38039 Kayseri, Turkey;Department of Pathology, Erciyes University, Medical School, 38039 Kayseri, Turkey;Department of Biostatistics and Medical In-formatics, Erciyes University, Medical School, 38039 Kayseri, Turkey
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Correspondence to: Mehmet Celikbilek, MD, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey. drcelikbilek@yahoo.com
Author contributions: Celikbilek M, Taheri S and Dogan S contributed to the design of the study, data collection, drafted the manuscript, and revised it in accordance with suggestions from the other authors; Baskol M contributed to the design of the study, drafted the manuscript and participated in the critical revision of the manuscript for important intellectual content; Deniz K contributed to the study conception and design, analysis and interpretation of data, drafted the manuscript, and participated in the critical revision of the manuscript for important intellectual content; Zararsız G performed the statistical and bioinformatics analysis; Gursoy S, Guven K, Ozbakır O, Dundar M, Yucesoy M contributed to the design of the study, interpretation of data, and participated in the critical revision of the manuscript for important intellectual content.
Telephone: +90-505-6615375 Fax: +90-354-2140612
ISSN:1948-5182
1948-5182
DOI:10.4254/wjh.v6.i8.613