Feibi decoction-medicated serum inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells and BMDMs

Feibi decoction (FBD) is a traditional Chinese herbal medicine and has been clinically used in the treatment of pulmonary fibrosis (PF), which is characterized by diffuse interstitial inflammation and exaggerated collagen accumulation. However, the potential mechanisms remain to be elucidated. The p...

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Bibliographic Details
Published inExperimental and therapeutic medicine Vol. 23; no. 1; p. 110
Main Authors Wei, Wan, Li, Guodong, Liu, Zhaoheng, Yang, Haojie, Liu, Shuo, Zou, Xinxin, Jiao, Yang
Format Journal Article
LanguageEnglish
Published Greece Spandidos Publications 01.01.2022
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects
Analysis
Biotechnology
Bone marrow
Care and treatment
Chinese medicine
Cytokines
Diagnosis
Dosage and administration
Experiments
Fibroblasts
Health aspects
Humidity
Inflammation
Laboratory animals
Lipopolysaccharides
Macrophages
Medicine, Chinese
Protein expression
Proteins
Pulmonary fibrosis
Respiratory agents
Risk factors
Software
Tumor necrosis factor-TNF
Variance analysis
China
Beijing China
inflammation
feibi decoction
pulmonary fibrosis
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Summary:Feibi decoction (FBD) is a traditional Chinese herbal medicine and has been clinically used in the treatment of pulmonary fibrosis (PF), which is characterized by diffuse interstitial inflammation and exaggerated collagen accumulation. However, the potential mechanisms remain to be elucidated. The present study aimed to investigate the effect of FBD-medicated serum (FBDS) on lipopolysaccharide (LPS)-induced inflammation in macrophages. In RAW264.7 macrophages and bone marrow-derived macrophages (BMDMs), FBDS treatment significantly inhibited the production of pro-inflammatory cytokines induced by LPS. In addition, it was indicated that FBDS treatment suppressed the activation of NF-κB and Smad2/Smad3 following LPS treatment. Furthermore, FBDS treatment decreased the expression of transforming growth factor-β1 and chitinase-3-like protein 1. In conclusion, the results demonstrated that treatment with FBDS inhibited LPS-induced inflammation in RAW264.7 and BMDM cells. These data may improve understanding of the effect of FBD on anti-inflammation and help determine the mechanisms underlying the alleviation of PF via FBD.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2021.11033