Acetylcholine receptors and acetylcholinesterase activity in soleus muscle of trembler dysmyelinating mutant: a cytochemical and biochemical analysis

We performed comparative biochemical and morphological studies of trembler and control soleus muscles. In the mutant, small multiple endplates were observed on some muscle fibers. The acetylcholine receptor (AChR) concentration and the acetylcholinesterase (AChE) activity of the muscle were not modi...

Full description

Saved in:
Bibliographic Details
Published inNeuroscience letters Vol. 65; no. 1; p. 72
Main Authors Do Thi, N A, Bon, C, Koenig, H L, Bourre, J M
Format Journal Article
LanguageEnglish
Published Ireland 28.03.1986
Subjects
Acetylcholinesterase - metabolism
Animals
Autoradiography
Mice
Mice, Neurologic Mutants
Motor Endplate - metabolism
Muscles - metabolism
Myelin Sheath
Neuromuscular Junction - metabolism
Peripheral Nervous System Diseases - metabolism
Receptors, Cholinergic - analysis
Receptors, Cholinergic - metabolism
Online AccessGet more information

Cover

More Information
Summary:We performed comparative biochemical and morphological studies of trembler and control soleus muscles. In the mutant, small multiple endplates were observed on some muscle fibers. The acetylcholine receptor (AChR) concentration and the acetylcholinesterase (AChE) activity of the muscle were not modified in the mutant. Our results suggest that both AChR and AChE levels are similar in trembler and control soleus but that these molecules are localized differently in the sarcolemma of the mutant muscles.
ISSN:0304-3940
DOI:10.1016/0304-3940(86)90122-9