High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids

AIM： To investigate whether high-fat-feeding is associ- ated with increased intestinal permeability via altera- tions in bile acid metabolism. METHODS： Male C57BI/6J mice were fed on a high-fat （n = 26） or low-fat diet （n = 24） for 15 wk. Intestinal permeability was measured from duodenum, jejunum,...

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Published inWorld journal of gastroenterology : WJG Vol. 18; no. 9; pp. 923 - 929
Main Author Stenman, Lotta K
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Co., Limited 07.03.2012
Subjects
Altera
Animals
Bile Acids and Salts - chemistry
Bile Acids and Salts - metabolism
Brief
Diet, Fat-Restricted
Diet, High-Fat - adverse effects
Feces - chemistry
Intestines - anatomy & histology
Intestines - physiopathology
Male
Mice
Mice, Inbred C57BL
Permeability
Random Allocation
Receptors, Cytoplasmic and Nuclear - metabolism
Tumor Necrosis Factor-alpha - metabolism
Ursodeoxycholic Acid - chemistry
Ursodeoxycholic Acid - metabolism
功能障碍
气相色谱分析
粪便
肠道
胆汁酸
通透性
高脂肪
Farnesoid X-activated receptor
Bile acids
Diet-induced obesity
Intestinal permeability
Bile salts
Ursodeoxycholic acid
Online AccessGet full text
ISSN1007-9327
2219-2840
2219-2840
DOI10.3748/wjg.v18.i9.923

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Summary:AIM： To investigate whether high-fat-feeding is associ- ated with increased intestinal permeability via altera- tions in bile acid metabolism. METHODS： Male C57BI/6J mice were fed on a high-fat （n = 26） or low-fat diet （n = 24） for 15 wk. Intestinal permeability was measured from duodenum, jejunum, ileum and colon in an Ussing chamber system using 4 kDa FITC-labeled dextran as an indicator. Fecal bile ac- ids were analyzed with gas chromatography. Segments of jejunum and colon were analyzed for the expression of farnesoid X receptor （FXR） and tumor necrosis factor
Bibliography:14-1219/R
Bile acids; Bile salts; Diet-induced obesity;Farnesoid X-activated receptor; Intestinal permeability;Ursodeoxycholic acid
AIM： To investigate whether high-fat-feeding is associ- ated with increased intestinal permeability via altera- tions in bile acid metabolism. METHODS： Male C57BI/6J mice were fed on a high-fat （n = 26） or low-fat diet （n = 24） for 15 wk. Intestinal permeability was measured from duodenum, jejunum, ileum and colon in an Ussing chamber system using 4 kDa FITC-labeled dextran as an indicator. Fecal bile ac- ids were analyzed with gas chromatography. Segments of jejunum and colon were analyzed for the expression of farnesoid X receptor （FXR） and tumor necrosis factor
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Correspondence to: Lotta Stenman, MSc, Institute of Biomedicine, Pharmacology, P.O.Box 63, FI-00014 University of Helsinki, Helsinki 00280, Finland. lotta.stenman@helsinki.fi
Author contributions: Stenman LK designed the study, performed the experiments, analyzed the data, and wrote the manuscript; Holma R and Korpela R were involved in designing the study and editing the manuscript.
Telephone: +358-9-19125354 Fax: +358-9-19125364
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v18.i9.923