Noninvasive Assessment of Endothelial Function: The Classic Methods and the New Peripheral Arterial Tonometry

The combination of risk stratification by assessment of conventional risk factors for cardiovascular disease (CVD) with not only a morphological assessment of vascular damage (such as carotid ultrasound examination) but also vascular function tests may be a useful strategy for the management of CVD...

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Bibliographic Details
Published inJournal of Investigative Medicine Vol. 62; no. 6; pp. 856 - 864
Main Authors Vizzardi, Enrico, Gavazzoni, Mara, Della Pina, Paolo, Bonadei, Ivano, Regazzoni, Valentina, Sciatti, Edoardo, Trichaki, Eleftheria, Raddino, Riccardo, Metra, Marco
Format Book Review Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.08.2014
Subjects
Animals
Arteries - physiology
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - physiopathology
Endothelium, Vascular - physiology
Humans
Manometry - trends
Microcirculation - physiology
Peripheral Arterial Disease - diagnosis
Peripheral Arterial Disease - physiopathology
endothelial function
EndoPAT
microcirculation
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Summary:The combination of risk stratification by assessment of conventional risk factors for cardiovascular disease (CVD) with not only a morphological assessment of vascular damage (such as carotid ultrasound examination) but also vascular function tests may be a useful strategy for the management of CVD and its related risk factors. Endothelial dysfunction is present in a great variety of pathological conditions: it is considered the first alteration of vascular function in atherosclerosis and one of the phenomena involved in the progression of heart failure. Assessing endothelial function with noninvasive methods could have a central role for evaluation of treatment, prognostic stratification, and pharmacological studies in CVD. In this review, we focus on noninvasive techniques that have recently become available to assess endothelial function and express the possible clinical role in different clinical settings.
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ISSN:1081-5589
1708-8267
DOI:10.1097/JIM.0000000000000096