Assessment of safety and feasibility of human allogeneic adipose-derived mesenchymal stem cells in a pediatric patient

To the Editor: Human adipose-derived mesenchymal stem cells (hAd-MSC) have been the subject of many investigations and has attracted significant attentions as to their potential therapeutic applications.1–3 Ad-MSC possess pleuripotential properties capable of differentiating into several types of ce...

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Published inPediatric research Vol. 84; no. 5; pp. 575 - 577
Main Authors Hirano, Atsuyuki, Sano, Masayuki, Urushihata, Naoki, Tanemura, Hideki, Oki, Katsuyuki, Suzaki, Emi
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.11.2018
Nature Publishing Group
Subjects
Children & youth
Correspondence
Medicine
Medicine & Public Health
Patient safety
Pediatric Surgery
Pediatrics
Stem cells
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Summary:To the Editor: Human adipose-derived mesenchymal stem cells (hAd-MSC) have been the subject of many investigations and has attracted significant attentions as to their potential therapeutic applications.1–3 Ad-MSC possess pleuripotential properties capable of differentiating into several types of cells such as adipocyte, myocyte, chondrocyte, and osteocyte.4 Intravenous administration of Ad-MSC showed accumulation mainly in the lungs, and also in the heart, liver, and brain.5 MSC has been used to help alleviate various disease conditions. Long-term follow-up of patients with ischemic stroke after MSC administration showed some improvement with no adverse effects after 5 years.6
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ISSN:0031-3998
1530-0447
1530-0447
DOI:10.1038/s41390-018-0042-8