Efficacy of Early (≤ 24 Hours), Late (25-72 Hours), and Delayed (>72 Hours) Surgery with Magnetic Resonance Imaging-Confirmed Decompression in American Spinal Injury Association Impairment Scale Grades C and D Acute Traumatic Central Cord Syndrome Caused by Spinal Stenosis

• Published in: Journal of neurotrauma Vol. 38; no. 15; p. 2073
• Main Authors: Aarabi, Bizhan, Akhtar-Danesh, Noori, Simard, J Marc, Chryssikos, Timothy, Shanmuganathan, Kathirkamanathan, Olexa, Joshua, Sansur, Charles A, Crandall, Kenneth M, Wessell, Aaron P, Cannarsa, Gregory, Sharma, Ashish, Lomangino, Cara D, Boulter, Jason, Scarboro, Maureen, Oliver, Jeffrey, Ahmed, Abdul Kareem, Wenger, Nicole, Serra, Riccardo, Shea, Phelan, Schwartzbauer, Gary T
• Format: Journal Article
• Language: English
• Published: United States 01.08.2021
• Subjects: Aged; Central Cord Syndrome - diagnostic imaging; Central Cord Syndrome - etiology; Central Cord Syndrome - surgery; Decompression, Surgical; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Activity; Recovery of Function; Retrospective Studies; Spinal Stenosis - complications; Spinal Stenosis - diagnostic imaging; Spinal Stenosis - surgery; Time-to-Treatment; Treatment Outcome; spinal cord injury; trauma; decompression; timing; outcome
• ISSN: 1557-9042
• DOI: 10.1089/neu.2021.0040

The therapeutic significance of timing of decompression in acute traumatic central cord syndrome (ATCCS) caused by spinal stenosis remains unsettled. We retrospectively examined a homogenous cohort of patients with ATCCS and magnetic resonance imaging (MRI) evidence of post-treatment spinal cord decompression to determine whether timing of decompression played a significant role in American Spinal Injury Association (ASIA) motor score (AMS) 6 months following trauma. We used the test, analysis of variance, Pearson correlation coefficient, and multiple regression for statistical analysis. During a 19-year period, 101 patients with ATCCS, admission ASIA Impairment Scale (AIS) grades C and D, and an admission AMS of ≤95 were surgically decompressed. Twenty-four of 101 patients had an AIS grade C injury. Eighty-two patients were males, the mean age of patients was 57.9 years, and 69 patients had had a fall. AMS at admission was 68.3 (standard deviation [SD] 23.4); upper extremities (UE) 28.6 (SD 14.7), and lower extremities (LE) 41.0 (SD 12.7). AMS at the latest follow-up was 93.1 (SD 12.8), UE 45.4 (SD 7.6), and LE 47.9 (SD 6.6). Mean number of stenotic segments was 2.8, mean canal compromise was 38.6% (SD 8.7%), and mean intramedullary lesion length (IMLL) was 23 mm (SD 11). Thirty-six of 101 patients had decompression within 24 h, 38 patients had decompression between 25 and 72 h, and 27 patients had decompression >72 h after injury. Demographics, etiology, AMS, AIS grade, morphometry, lesion length, surgical technique, steroid protocol, and follow-up AMS were not statistically different between groups treated at different times. We analyzed the effect size of timing of decompression categorically and in a continuous fashion. There was no significant effect of the timing of decompression on follow-up AMS. Only AMS at admission determined AMS at follow-up (coefficient = 0.31; 95% confidence interval [CI]:0.21;  = 0.001). We conclude that timing of decompression in ATCCS caused by spinal stenosis has little bearing on ultimate AMS at follow-up.