Isoplatensimycin: Synthesis and biological evaluation

• Published in: Bioorganic & medicinal chemistry letters Vol. 19; no. 16; pp. 4601 - 4602
• Main Authors: Jang, Ki Po, Kim, Chan Hyuk, Na, Seong Wook, Kim, Hiyoung, Kang, Heonjoong, Lee, Eun
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 15.08.2009; Elsevier
• Subjects: Adamantane - analogs & derivatives; Adamantane - chemical synthesis; Adamantane - chemistry; Adamantane - pharmacology; Aminobenzoates - chemical synthesis; Aminobenzoates - chemistry; Aminobenzoates - pharmacology; Anilides - chemical synthesis; Anilides - chemistry; Anilides - pharmacology; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibiotic; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Enterococcus - drug effects; General aspects; Isoplatensimycin; Medical sciences; Methicillin-Resistant Staphylococcus aureus - drug effects; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Platensimycin; Staphylococcus aureus; Vancomycin Resistance; Antibiotic; Isoplatensimycin; Platensimycin; Enterococcus faecalis; Vancomycin; In vitro; Biological activity; Meticillin; Resistance; Streptococcaceae; Enterococcus faecium; Bacteria; Micrococcales; Micrococcaceae; Chemical synthesis; Staphylococcus aureus
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2009.06.092

Isoplatensimycin retains activities against some vancomycin-resistant enteroccoci. Isoplatensimycin, a novel analog of platensimycin, was synthesized via intramolecular dipolar cycloaddition of a carbonyl ylide. Isoplatensimycin showed little activities against strains of Staphylococcus aureus, but exhibited activities against some vancomycin-resistant enteroccoci.