Diabetes and Alzheimer’s Disease: A Link not as Simple as it Seems

Type 2 diabetes mellitus is associated with an increased risk to develop Alzheimer disease, however, the underlying mechanisms for this association are still unclear. In this review we will provide a critical overview of the major findings coming from clinical studies and animal models.

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Bibliographic Details
Published inNeurochemical research Vol. 44; no. 6; pp. 1271 - 1278
Main Authors Salas, Isabel H., De Strooper, Bart
Format Journal Article
LanguageEnglish
Published New York Springer US 01.06.2019
Springer Nature B.V
Subjects
Alzheimer Disease - complications
Alzheimer Disease - pathology
Alzheimer's disease
Amyloidosis - complications
Animal models
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Brain - pathology
Cell Biology
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - pathology
Health risks
Humans
Insulin Resistance - physiology
Neurochemistry
Neurodegenerative diseases
Neurology
Neurosciences
Review Paper
Risk Factors
Signal Transduction - physiology
Alzheimer’s disease
Amyloid
Cognition
Diabetes
Insulin
Glycemia
Metabolic stress
Dementia
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Summary:Type 2 diabetes mellitus is associated with an increased risk to develop Alzheimer disease, however, the underlying mechanisms for this association are still unclear. In this review we will provide a critical overview of the major findings coming from clinical studies and animal models.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-018-2690-9