Morphological studies of bone and tendon

The Soviet biosatellite COSMOS 2044 carried adult rats on a spaceflight that lasted 13.8 days and was intended to repeat animal studies carried out on COSMOS 1887. Skeletal tissue and tendon from animals flown on COSMOS 2044 were studied by light and electron microscopy, histochemistry, and morphome...

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Published inJournal of applied physiology (1985) Vol. 73; no. 2 Suppl; p. 10S
Main Authors Doty, S B, Morey-Holton, E R, Durnova, G N, Kaplansky, A S
Format Journal Article
LanguageEnglish
Published United States 01.08.1992
Subjects
Adaptation, Physiological
Animals
Bone and Bones - anatomy & histology
Bone and Bones - blood supply
Bone and Bones - physiology
Collagen - metabolism
Histocytochemistry
Male
Microscopy, Electron
Osteoblasts - physiology
Osteoblasts - ultrastructure
Rats
Rats, Inbred Strains
Regional Blood Flow - physiology
Space Flight
Tendons - anatomy & histology
Tendons - blood supply
Tendons - physiology
Tibia - blood supply
Tibia - physiology
Tibia - ultrastructure
NASA Center ARC
NASA Discipline Musculoskeletal
Non-NASA Center
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Summary:The Soviet biosatellite COSMOS 2044 carried adult rats on a spaceflight that lasted 13.8 days and was intended to repeat animal studies carried out on COSMOS 1887. Skeletal tissue and tendon from animals flown on COSMOS 2044 were studied by light and electron microscopy, histochemistry, and morphometric techniques. Studies were confined to the bone cells and vasculature from the weight-bearing tibias. Results indicated that vascular changes at the periosteal and subperiosteal region of the tibia were not apparent by light microscopy or histochemistry. However, electron microscopy indicated that vascular inclusions were present in bone samples from the flight animals. A unique combination of microscopy and histochemical techniques indicated that the endosteal osteoblasts from this same mid-diaphyseal region demonstrated a slight (but not statistically significant) reduction in bone cell activity. Electron-microscopic studies of the tendons from metatarsal bones showed a collagen fibril disorganization as a result of spaceflight. Thus changes described for COSMOS 1887 were present in COSMOS 2044, but the changes ascribed to spaceflight were not as evident.
ISSN:8750-7587
DOI:10.1152/jappl.1992.73.2.s10