Species specificity of thrombin-induced changes in vascular tone
We studied the effects of acetylcholine and human thrombin on the tone of rabbit and dog isolated femoral arteries and aortas with intact endothelium. Acetylcholine (10(-9)-10(-6) mol/l) produced relaxation in the vessels from both species whereas thrombin (10(-9)-3 X 10(-8) mol/l) relaxed only cani...
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Published in | European journal of pharmacology Vol. 132; no. 1; p. 71 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
02.12.1986
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Subjects | |
Online Access | Get more information |
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Summary: | We studied the effects of acetylcholine and human thrombin on the tone of rabbit and dog isolated femoral arteries and aortas with intact endothelium. Acetylcholine (10(-9)-10(-6) mol/l) produced relaxation in the vessels from both species whereas thrombin (10(-9)-3 X 10(-8) mol/l) relaxed only canine arterial smooth muscle. Thrombin pretreatment increased significantly the relaxant potency of acetylcholine in femoral arteries of dogs. The results suggest an interspecies difference in the thrombin-induced endothelium-dependent vasorelaxation. |
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ISSN: | 0014-2999 |
DOI: | 10.1016/0014-2999(86)90012-9 |