Species specificity of thrombin-induced changes in vascular tone

We studied the effects of acetylcholine and human thrombin on the tone of rabbit and dog isolated femoral arteries and aortas with intact endothelium. Acetylcholine (10(-9)-10(-6) mol/l) produced relaxation in the vessels from both species whereas thrombin (10(-9)-3 X 10(-8) mol/l) relaxed only cani...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 132; no. 1; p. 71
Main Authors Gebremedhin, D, Ballagi-Pordány, G, Hadházy, P, Magyar, K, Machovich, R
Format Journal Article
LanguageEnglish
Published Netherlands 02.12.1986
Subjects
Acetylcholine - pharmacology
Animals
Dogs
Endothelium - physiology
Female
In Vitro Techniques
Male
Rabbits
Species Specificity
Thrombin - pharmacology
Vasodilation - drug effects
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Summary:We studied the effects of acetylcholine and human thrombin on the tone of rabbit and dog isolated femoral arteries and aortas with intact endothelium. Acetylcholine (10(-9)-10(-6) mol/l) produced relaxation in the vessels from both species whereas thrombin (10(-9)-3 X 10(-8) mol/l) relaxed only canine arterial smooth muscle. Thrombin pretreatment increased significantly the relaxant potency of acetylcholine in femoral arteries of dogs. The results suggest an interspecies difference in the thrombin-induced endothelium-dependent vasorelaxation.
ISSN:0014-2999
DOI:10.1016/0014-2999(86)90012-9