Similarity in drugs: reflections on analogue design
A survey of novel small-molecule therapeutics reveals that the majority of them result from analogue design and that their market value represents two-thirds of all small-molecule sales. In natural science, the term analogue, derived from the Latin and Greek analogia, has always been used to describ...
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Published in | Drug discovery today Vol. 11; no. 7; pp. 348 - 354 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.04.2006
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | A survey of novel small-molecule therapeutics reveals that the majority of them result from analogue design and that their market value represents two-thirds of all small-molecule sales. In natural science, the term analogue, derived from the Latin and Greek
analogia, has always been used to describe structural and functional similarity. Extended to drugs, this definition implies that the analogue of an existing drug molecule shares structural and pharmacological similarities with the original compound. Formally, this definition allows the establishment of three categories of drug analogues: analogues possessing chemical and pharmacological similarities (direct analogues); analogues possessing structural similarities only (structural analogues); and chemically different compounds displaying similar pharmacological properties (functional analogues). |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1359-6446 1878-5832 |
DOI: | 10.1016/j.drudis.2006.02.006 |