Early life risk factors and their cumulative effects as predictors of overweight in Spanish children

• Published in: International journal of public health Vol. 63; no. 4; pp. 501 - 512
• Main Authors: Iguacel, Isabel, Escartín, Laura, Fernández-Alvira, Juan M., Iglesia, Iris, Labayen, Idoia, Moreno, Luis A., Samper, María Pilar, Rodríguez, Gerardo
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2018; Springer Nature B.V
• Subjects: Birth Weight; Breast Feeding - adverse effects; Child; Child, Preschool; Children & youth; Childrens health; Environmental Health; Female; Gestational Age; Humans; Logistic Models; Male; Medicine; Medicine & Public Health; Obesity; Occupational Medicine/Industrial Medicine; Original Article; Pediatric Obesity - etiology; Pregnancy; Prenatal Exposure Delayed Effects; Public Health; Risk Factors; Prevention; Pregnancy; Children; Early life risk factors; Overweight
• ISSN: 1661-8556; 1661-8564
• DOI: 10.1007/s00038-018-1090-x

Objectives To explore early life risk factors of overweight/obesity at age 6 years and their cumulative effects on overweight/obesity at ages 2, 4 and 6 years. Methods Altogether 1031 Spanish children were evaluated at birth and during a 6-year follow-up. Early life risk factors included: parental overweight/obesity, parental origin/ethnicity, maternal smoking during pregnancy, gestational weight gain, gestational age, birth weight, caesarean section, breastfeeding practices and rapid infant weight gain collected via hospital records. Cumulative effects were assessed by adding up those early risk factors that significantly increased the risk of overweight/obesity. We conducted binary logistic regression models. Results Rapid infant weight gain (OR 2.29, 99% CI 1.54–3.42), maternal overweight/obesity (OR 1.93, 99% CI 1.27–2.92), paternal overweight/obesity (OR 2.17, 99% CI 1.44–3.28), Latin American/Roma origin (OR 3.20, 99% CI 1.60–6.39) and smoking during pregnancy (OR 1.61, 99% CI 1.01–2.59) remained significant after adjusting for confounders. A higher number of early life risk factors accumulated was associated with overweight/obesity at age 6 years but not at age 2 and 4 years. Conclusions Rapid infant weight gain, parental overweight/obesity, maternal smoking and origin/ethnicity predict childhood overweight/obesity and present cumulative effects. Monitoring children with rapid weight gain and supporting a healthy parental weight are important for childhood obesity prevention.