Celecoxib: a potent cyclooxygenase-2 inhibitor in cancer prevention

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used therapeutic agents in the treatment of pain, inflammation and fever. They may also have a role in the management of cancer prevention, Alzheimer’s disease and prophylaxis against cardiovascular disease. These drugs act primarily...

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Bibliographic Details
Published inCancer Detection and Prevention Vol. 28; no. 2; pp. 127 - 142
Main Authors Kısmet, Kemal, Akay, M.Turan, Abbasoǧlu, Osman, Ercan, Aygün
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 2004
Subjects
Anticarcinogenic Agents - pharmacokinetics
Anticarcinogenic Agents - therapeutic use
Apoptosis
Celecoxib
Chemoprevention
Cyclooxygenase
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors - therapeutic use
Humans
Isoenzymes - antagonists & inhibitors
Membrane Proteins
Neoplasms - prevention & control
Non-steroidal anti-inflammatory drugs
Prostaglandin-Endoperoxide Synthases
Pyrazoles
Sulfonamides - pharmacokinetics
Sulfonamides - therapeutic use
Cyclooxygenase
Celecoxib
Chemoprevention
Non-steroidal anti-inflammatory drugs
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Summary:Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used therapeutic agents in the treatment of pain, inflammation and fever. They may also have a role in the management of cancer prevention, Alzheimer’s disease and prophylaxis against cardiovascular disease. These drugs act primarily by inhibiting cyclooxygenase enzyme, which has two isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Selective COX-2 inhibitors provide potent anti-inflammatory and analgesic effects without the side effects of gastric and renal toxicity and inhibition of platelet function. Celecoxib is a potent COX-2 inhibitor being developed for the treatment of rheumatoid arthritis and osteoarthritis. Chemoprevention is the use of pharmacological or natural agents to prevent, suppress, interrupt or reverse the process of carcinogenesis. For this purpose, celecoxib is being used for different cancer types. The effects of NSAIDs on tumor growth remain unclear, but are most likely to be multifocal. In this article, we reviewed COX-2 selectivity, the pharmacological properties of celecoxib, the use of celecoxib for cancer prevention and the mechanisms of chemoprevention.
ISSN:0361-090X
1873-443X
DOI:10.1016/j.cdp.2003.12.005