Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification

• Published in: International journal of molecular sciences Vol. 22; no. 22; p. 12248
• Main Authors: Cavaliere, Anna Franca, Perelli, Federica, Zaami, Simona, D’Indinosante, Marco, Turrini, Irene, Giusti, Marco, Gullo, Giuseppe, Vizzielli, Giuseppe, Mattei, Alberto, Scambia, Giovanni, Vidiri, Annalisa, Signore, Fabrizio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.11.2021; MDPI
• Subjects: Age; Biopsy; Cancer therapies; Combined Modality Therapy; Contraindications; Disease; Endometrial cancer; Endometrial Neoplasms - classification; Endometrial Neoplasms - genetics; Endometrial Neoplasms - therapy; Female; Fertility; Fertility - physiology; Fertility Preservation - methods; Gynecological cancer; Health risk assessment; Humans; Hyperplasia; Hysteroscopy - methods; Infertility; Laparoscopy; Laparotomy; Lymphatic system; Medical prognosis; Mutation; Obesity; Organ Sparing Treatments - methods; Outcome Assessment, Health Care - methods; Outcome Assessment, Health Care - statistics & numerical data; Patients; Progestins - therapeutic use; Remission (Medicine); Response rates; Review; Surgery; Surgical outcomes; Tumors; Womens health; molecular biology; endometrial cancer; obstetric outcomes; fertility sparing; pregnancy
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms222212248

Endometrial cancer is the most frequent gynecological malignancy, and, although epidemiologically it mainly affects advanced age women, it can also affect young patients who want children and who have not yet completed their procreative project. Fertility sparing treatments are the subject of many studies and research in continuous evolution, and represent a light of hope for young cancer patients who find themselves having to face an oncological path before fulfilling their desire for motherhood. The advances in molecular biology and the more precise clinical and prognostic classification of endometrial cancer based on the 2013 The Cancer Genome Atlas classification allow for the selection of patients who can be submitted to fertility sparing treatments with increasing oncological safety. It would also be possible to predict the response to hormonal treatment by investigating the state of the genes of the mismatch repair.