CCR5 is characteristic of Th1 lymphocytes

• Published in: Nature (London) Vol. 391; no. 6665; pp. 344 - 345
• Main Authors: Loetscher, Pius, Uguccioni, Mariagrazia, Bordoli, Lorenza, Baggiolini, Marco, Moser, Bernhard, Chizzolini, Carlo, Dayer, Jean-Michel
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 22.01.1998
• Subjects: AIDS/HIV; Allergies; Arthritis, Rheumatoid - immunology; Chemokines; Clone Cells; Fetal Blood; Genotype & phenotype; Humans; Lymphocyte Activation; Lymphocytes; Parasites; Physics; Receptors, CCR5 - metabolism; Receptors, Chemokine - metabolism; Receptors, CXCR3; Th1 Cells - metabolism; Th2 Cells - metabolism; New York; United States > US; Germany; Michigan

CD4+ lymphocytes can be assigned to two subsets. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites...