CCR5 is characteristic of Th1 lymphocytes

CD4+ lymphocytes can be assigned to two subsets. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites...

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Published inNature (London) Vol. 391; no. 6665; pp. 344 - 345
Main Authors Loetscher, Pius, Uguccioni, Mariagrazia, Bordoli, Lorenza, Baggiolini, Marco, Moser, Bernhard, Chizzolini, Carlo, Dayer, Jean-Michel
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 22.01.1998
Subjects
AIDS/HIV
Allergies
Arthritis, Rheumatoid - immunology
Chemokines
Clone Cells
Fetal Blood
Genotype & phenotype
Humans
Lymphocyte Activation
Lymphocytes
Parasites
Physics
Receptors, CCR5 - metabolism
Receptors, Chemokine - metabolism
Receptors, CXCR3
Th1 Cells - metabolism
Th2 Cells - metabolism
New York
United States > US
Germany
Michigan
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Summary:CD4+ lymphocytes can be assigned to two subsets. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the chemokine receptor CCR3 (refs 2 b3). We have studied the occurrence of two additional chemokine receptors, CCR5 and CXCR3, in human, antigen-specific CD4+ Th1 and Th2 cell clones.
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ISSN:0028-0836
1476-4687
DOI:10.1038/34814