Synthesis and biological evaluation of C-12′ substituted vinflunine derivatives

• Published in: Bioorganic & medicinal chemistry Vol. 18; no. 16; pp. 4602 - 4605
• Main Authors: Sheng, Lei Xin, Da, Yu Xiang, Long, Yin, Hong, Liu Zhen, Cho, Tang Peng
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15.08.2008; Elsevier
• Subjects: A549 cell lines; Antineoplastic agents; Antineoplastic Agents, Phytogenic - chemical synthesis; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; Cell Line, Tumor; Chemistry, Pharmaceutical - methods; Drug Design; Drug Screening Assays, Antitumor; General aspects; Humans; In vitro; Inhibitory Concentration 50; Medical sciences; Microtubules - chemistry; Models, Chemical; Molecular Conformation; Pharmacology. Drug treatments; Sodium Azide - pharmacology; Synthesized; Tubulin - chemistry; Vinblastine - analogs & derivatives; Vinblastine - chemical synthesis; Vinblastine - chemistry; Vinblastine - pharmacology; Vinflunine derivatives; Vinflunine derivatives; In vitro; Synthesized; A549 cell lines; Antineoplastic agent; Pentacyclic compound; Human; Angular nitrogen heterocycle; Nitrogen heterocycle; Lung; Cytotoxicity; Tetracyclic compound; Ester; Alkaloid; Cell line; Structure activity relation; Aromatic compound; Fluorine Organic compounds; Chemical synthesis; Acylate; Tumor cell; Glycol
• ISSN: 0960-894X; 0968-0896; 1464-3405; 1464-3391
• DOI: 10.1016/j.bmcl.2008.07.025

A series of novel C-12′ substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines. A series of novel C-12′ substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines.