Emerging Therapeutic Potential of Mesenchymal Stem/Stromal Cells in Preeclampsia

Purpose of Review Preeclampsia is a dangerous pregnancy condition affecting both the mother and offspring. It is a multifactorial disease with poorly understood pathogenesis, lacking effective treatments. Maternal immune response, inflammation and oxidative stress leading to endothelial dysfunction...

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Bibliographic Details
Published inCurrent hypertension reports Vol. 22; no. 5; p. 37
Main Authors Suvakov, S., Richards, C., Nikolic, V., Simic, T., McGrath, K., Krasnodembskaya, A., McClements, L.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.05.2020
Springer Nature B.V
Subjects
Animals
Apoptosis
Cardiology
Chemokines
Family Medicine
Female
General Practice
Growth factors
Humans
Hypertension
Inflammation
Internal Medicine
Medicine
Medicine & Public Health
Mesenchymal Stem Cells
Metabolic Diseases
Metabolism
Nephrology
Oxidative stress
Pathogenesis
Placenta
Pre-Eclampsia - therapy
Preeclampsia
Preeclampsia (VD Garovic
Pregnancy
Primary Care Medicine
Section Editor
Topical Collection on Preeclampsia
Tumor necrosis factor-TNF
Extracellular vesicles
Biological therapies preeclampsia
Preeclampsia
Mesenchymal stem cells
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Summary:Purpose of Review Preeclampsia is a dangerous pregnancy condition affecting both the mother and offspring. It is a multifactorial disease with poorly understood pathogenesis, lacking effective treatments. Maternal immune response, inflammation and oxidative stress leading to endothelial dysfunction are the most prominent pathogenic processes implicated in preeclampsia development. Here, we give a detailed overview of the therapeutic applications and mechanisms of mesenchymal stem/stromal cells (MSCs) as a potential new treatment for preeclampsia. Recent Findings MSCs have gained growing attention due to low immunogenicity, easy cultivation and expansion in vitro. Accumulating evidence now suggests that MSCs act primarily through their secretomes facilitating paracrine signalling that leads to potent immunomodulatory, pro-angiogenic and regenerative therapeutic effects. Summary MSCs have been studied in different animal models of preeclampsia demonstrating promising result, which support further investigations into the therapeutic effects and mechanisms of MSC-based therapies in preeclampsia, steering these therapies into clinical trials.
ISSN:1522-6417
1534-3111
DOI:10.1007/s11906-020-1034-8