Evaluation of nitroalkenes as nitric oxide donors

Nitroalkenes decompose to small amounts of NO as judged by chemiluminescence NO detection. Chemiluminescence experiments demonstrate that simple nitroalkenes release low levels of nitric oxide. UV and EPR measurements suggest but cannot confirm direct NO release from nitroalkenes. Given the biologic...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 17; no. 7; pp. 2013 - 2017
Main Authors Gorczynski, Michael J., Huang, Jinming, Lee, Heather, King, S. Bruce
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.04.2007
Elsevier
Subjects
Alkenes - chemical synthesis
Alkenes - chemistry
Chemistry
Chemistry, Pharmaceutical - methods
Dose-Response Relationship, Drug
Drug Design
Electron Spin Resonance Spectroscopy
Exact sciences and technology
Free radicals
Luminescence
Models, Chemical
Molecular Conformation
Nitric oxide
Nitric Oxide - chemistry
Nitric Oxide Donors
Nitro Compounds - chemistry
Nitroalkenes
Organic chemistry
Spectrophotometry, Ultraviolet
Time Factors
Nitric oxide donors
Free radicals
Nitroalkenes
Nitric oxide
Nitro compound
EPR spectrometry
Chemiluminescence
Ultraviolet spectrometry
Biological activity
Free radical
Nitric oxide donor
Unsaturated fatty acid
Ethylenic compound
Release
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Summary:Nitroalkenes decompose to small amounts of NO as judged by chemiluminescence NO detection. Chemiluminescence experiments demonstrate that simple nitroalkenes release low levels of nitric oxide. UV and EPR measurements suggest but cannot confirm direct NO release from nitroalkenes. Given the biological activity of nitrated unsaturated fatty acids, these results suggest the possible metabolic conversion of nitroalkenes to NO.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2007.01.016