Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones

• Published in: Bioorganic & medicinal chemistry Vol. 18; no. 24; pp. 6462 - 6467
• Main Authors: Singh, Okram Mukherjee, Singh, Sarangthem Joychandra, Devi, Mutum Babita, Devi, Laitonjam Nalini, Singh, Nameirakpam Irabanta, Lee, Sang-Gyeong
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 15.12.2008; Elsevier
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal activity; Antifungal agents; Antifungal Agents - chemical synthesis; Antifungal Agents - pharmacology; Aspergillus niger; Aspergillus niger - metabolism; Biological and medical sciences; Catalysis; Chemistry, Pharmaceutical - methods; Copper - chemistry; Dihydropyrimidine; Drug Design; In Vitro Techniques; Medical sciences; Microbial Sensitivity Tests; Models, Chemical; Pharmacology. Drug treatments; Pyrimidinones - chemical synthesis; Pyrimidinones - pharmacology; Solvent-free; Solvents - chemistry; Time Factors; Trichoderma - metabolism; Trichoderma koningii; Dihydropyrimidine; Antifungal activity; Solvent-free; Trichoderma; Pyrimidone derivatives; In vitro; Biological activity; Fungi; Antifungal agent; Aspergillus niger; Solvent free; Pyrimidine derivatives; Biginelli reaction; Fungi Imperfecti; Chemical synthesis
• ISSN: 0960-894X; 0968-0896; 1464-3405; 1464-3391
• DOI: 10.1016/j.bmcl.2008.10.063

The synthesis of dihydropyridines under solvent-free conditions catalyzed by cupric chloride and their antifungal activities are reported. Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80–96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz., Trichoderma hammatum, Trichoderma koningii and Aspergillus niger.