Complex segregation analysis of facial melasma in Brazil: evidence for a genetic susceptibility with a dominant pattern of segregation

Despite high prevalence, the etiopathology of melasma is not fully understood. Nevertheless, many factors have been associated with the disease, including: sun exposure, sex steroids hormones, drugs, stress, and pregnancy. The high occurrence within familiars (40–60%) suggests a genetic predispositi...

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Published inArchives of Dermatological Research Vol. 310; no. 10; pp. 827 - 831
Main Authors Holmo, Nicole França, Ramos, Geovana Brotto, Salomão, Heloisa, Werneck, Renata Iani, Mira, Marcelo Távora, Miot, Luciane Donida Bartoli, Miot, Hélio Amante
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2018
Springer Nature B.V
Subjects
Adult
Brazil - epidemiology
Case-Control Studies
Chromosome Segregation - genetics
Concise Communication
Dermatology
Epidemiology
Face - pathology
Female
Genes, Dominant - genetics
Genetic Predisposition to Disease - genetics
Heredity
Hormones
Humans
Male
Medicine
Medicine & Public Health
Melanosis - epidemiology
Melanosis - genetics
Middle Aged
Pregnancy
Risk Factors
Skin
Skin - pathology
Steroid hormones
Sun
Brazil
Genetics
Heredity
Melasma
Inheritance patterns
Pigmentary disorders
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Summary:Despite high prevalence, the etiopathology of melasma is not fully understood. Nevertheless, many factors have been associated with the disease, including: sun exposure, sex steroids hormones, drugs, stress, and pregnancy. The high occurrence within familiars (40–60%) suggests a genetic predisposition to the disease. This study explored, through complex segregation analysis (CSA), the inheritance model that best fit the family segregation pattern of facial melasma when accounting for the main epidemiological risk factors. We evaluated 686 subjects from 67 families, and 260 (38%) of them had facial melasma. The CSA model, adjusted for age, skin phototype, sex, sun exposure at work, hormonal oral contraceptive, and pregnancy, evidenced a genetic component that was best fitted to a dominant pattern of segregation. Melasma results from an interaction between exposure factors (e.g. pregnancy, hormones, and sun exposure) over genetically predisposed individuals.
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ISSN:0340-3696
1432-069X
1432-069X
DOI:10.1007/s00403-018-1861-5