IgG subclasses in patients with membranoproliferative glomerulonephritis, membranous nephropathy, and lupus nephritis

• Published in: Kidney international Vol. 51; no. 1; pp. 270 - 276
• Main Authors: Imai, Hirokazu, Hamai, Keiko, Komatsuda, Atsushi, Ohtani, Hiroshi, Miura, Akira B.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.1997; Nature Publishing
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Female; Fluorescent Antibody Technique; Glomerulonephritis; Glomerulonephritis, Membranoproliferative - immunology; Glomerulonephritis, Membranous - immunology; Humans; Immunoglobulin G - blood; Lupus Nephritis - immunology; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Kidney disease; Human; Immunohistochemistry; Lupus; Glomerulonephritis; Pathology; Skin disease; Molecular form; Urinary system disease; Classification; IgG; Mesangial proliferative glomerulonephritis
• ISSN: 0085-2538; 1523-1755
• DOI: 10.1038/ki.1997.32

IgG subclasses in patients with membranoproliferative glomerulonephritis, membranous nephropathy, and lupus nephritis. Primary glomerulopathy can be classified into seven essential patterns based on histopathological studies. The pathogenesis of membranoproliferative glomerulonephritis (MPGN), and membranous nephropathy (MN), which show glomerular IgG deposition and induce mainely nephrotic syndrome, is not known. To clarify the role of IgG subclass in glomerulonephritis, we compared serum concentrations of IgG subclasses, the ratio of serum IgG subclasses to total IgG (%IgG subclass), and glomerular deposition of IgG subclasses between 7 MPGN patients, 21 MN patients, and 9 lupus nephritis (LN) patients. Serum IgG subclasses and %IgG in all groups were almost within normal range based on the values in Japanese healthy adults. In the MPGN and MN groups, the IgG1 concentration was significant lower than that of the LN group (P < 0.001, P < 0.0001, respectively). The IgG2 concentration in the MPGN group decreased significantly compared with that in the LN group (P < 0.05). The %IgG2 of the LN group decreased significantly compared with that of the MN group (P < 0.05). The %IgG3 of the MPGN group was significantly higher than that of the MN group (P < 0.05). The glomerular immunoflourescent intensity of IgG1 and IgG2 were significantly stronger in the LN group than in the MPGN and MN groups (IgG1, P < 0.001, P < 0.01, respectively; IgG2, P < 0.0001, P < 0.0001, respectively). IgG3 in the MPGN and LN groups deposited significantly compared with that in the MN group (P < 0.0001, P < 0.01, respectively). The intensity of IgG4 in the MN group showed a significant difference compared with that in the MPGN and LN groups (P < 0.0001, P < 0.01, respectively). IgG3 is an important factor in the pathogenesis of primary MPGN, while IgG4 relates to glomerular IgG deposition in MN.