Association of MMP2-1306C/T Polymorphism with Ischemic Retinal Vein Occlusion

• Published in: Archives of medical research Vol. 51; no. 7; pp. 710 - 713
• Main Authors: Christodoulou, Aikaterini, Bagli, Eleni, Gazouli, Maria, Moschos, Marilita M., Kitsos, George
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2020
• Subjects: Aged; Female; Genetic Predisposition to Disease - genetics; Humans; Ischemia; Male; Matrix Metalloproteinase 2 - genetics; Matrix metalloproteinases; MMP2; MMP2-1306C/T; Polymorphism; Polymorphism, Genetic - genetics; Retinal vein occlusion; Retinal Vein Occlusion - genetics; Retinal vein occlusion; MMP2-1306C/T; Matrix metalloproteinases; Ischemia; MMP2; Polymorphism
• ISSN: 0188-4409; 1873-5487; 1873-5487
• DOI: 10.1016/j.arcmed.2020.06.015

To investigate the possible association of the matrix metalloproteinase 2 (MMP2)-1306C/T polymorphism with the risk of ischemic retinal vein occlusion (iRVO). A total of 69 patients with RVO were enrolled in this study (43 with non-iRVO and 26 with iRVO). All subjects were screened for hypertension, diabetes mellitus, hyperlipidemia, history of stroke, anticoagulant medication, smoking status and glaucoma. The genotyping of MMP2-1306C/T polymorphism was performed using PCR-RFLP-based methods. MMP2-1306C/T T allele carriers (CT+TT) were statistically significant associated with a higher risk of iRVO compared to CC genotype in the overall RVO group (odds ratio = 3.91, p = 0.015, 95% confidence interval:1.30–11.79). Analysis, following stratification by age revealed that T allele carriers had a statistically significant increased risk of iRVO compared to C allele carriers only in RVO patients <75 years old. Our results demonstrated that MMP2-1306C/T polymorphism is a likely predisposing factor for iRVO in patients <75 years old. This is the first study attempting association of a gene polymorphism with the prevalence of iRVO.