Study of the binding in an aqueous medium of inclusion complexes of several cyclodextrins involving fenoprofen calcium

Interactions among fenoprofen calcium and alpha-, beta-, gamma- and hydroxypropyl-beta-cyclodextrins (HP-beta-CD) were evaluated in aqueous solution by UV/vis and fluorescence direct spectroscopies and monodimensional (1D) 1H-NMR. Different UV/vis and fluorescence emission spectra were obtained to s...

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Bibliographic Details
Published inDrug development and industrial pharmacy Vol. 25; no. 1; p. 107
Main Authors Díaz, D, Escobar Llanos, C M, Bernad Bernad, M J
Format Journal Article
LanguageEnglish
Published England 01.01.1999
Subjects
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Chemistry, Pharmaceutical
Cyclodextrins - chemistry
Fenoprofen - chemistry
Magnetic Resonance Spectroscopy
Spectrometry, Fluorescence
Spectrophotometry
Spectrophotometry, Ultraviolet
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Summary:Interactions among fenoprofen calcium and alpha-, beta-, gamma- and hydroxypropyl-beta-cyclodextrins (HP-beta-CD) were evaluated in aqueous solution by UV/vis and fluorescence direct spectroscopies and monodimensional (1D) 1H-NMR. Different UV/vis and fluorescence emission spectra were obtained to study the apparent binding constants (K) to define the most appropriate cyclodextrin to form the inclusion complexes (IC). beta-CD and HP-beta-CD clearly fit the magnitude of stability constant data of the complexes to take into account the pharmaceutical technology interest.
ISSN:0363-9045
1520-5762
DOI:10.1081/DDC-100102150