Two new lankacidin-related metabolites from Streptomyces sp. HS-NF-1178

• Published in: Journal of antibiotics Vol. 71; no. 3; pp. 397 - 401
• Main Authors: Lu, Chang, Li, Jin-Meng, Qi, Huan, Zhang, Hui, Zhang, Ji, Xiang, Wen-Sheng, Wang, Ji-Dong, Wang, Xiang-Jing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2018; Japan Antibiotics Research Assoc; Nature Publishing Group
• Subjects: 631/154/309/2144; 631/67/1059/153; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics, Antineoplastic - isolation & purification; Antibiotics, Antineoplastic - pharmacology; Bacteria - drug effects; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Brief Communication; Cell Line, Tumor; Drug Screening Assays, Antitumor; Fermentation; Humans; Immunology; Life Sciences; Life Sciences & Biomedicine; Macrolides - chemistry; Macrolides - isolation & purification; Macrolides - pharmacology; Magnetic Resonance Spectroscopy; Medicinal Chemistry; Metabolites; Microbial Sensitivity Tests; Microbiology; Organic Chemistry; Pharmacology & Pharmacy; Science & Technology; Spectrometry, Mass, Electrospray Ionization; Streptomyces - chemistry; Streptomyces - metabolism; MECHANISM; GROUP T-2636 ANTIBIOTICS; CHEMICAL-STRUCTURES
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/s41429-017-0004-0

Two new lankacidin-related metabolites, 2,18-seco-lankacidinol A ( 1 ), 2,18-seco-lankacidinol B ( 2 ) and a known compound, lankacidinol ( 3 ), were isolated from the fermentation broth of Streptomyces sp. HS-NF-1178. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. These two new compounds, especially compound 1 , exhibited potent antitumor activity.