Idarubicin, an Anthracycline, Induces Oxidative DNA Damage in the Presence of Copper (II)

Background/Aim: The aim of the present study was to investigate whether idarubicin (IDR) induces oxidative DNA damage in the presence of copper (II). Materials and Methods: DNA damage was evaluated by pBR322 plasmid DNA cleavage. The formation of oxidative stress markers [O2•− and 8-hydroxy-2'-...

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Published inAnticancer research Vol. 40; no. 10; pp. 5399 - 5404
Main Authors MIZUTANI, HIDEKI, SHIGA, CHIAKI, IMAI, MASANORI, IKEMURA, KENJI, KITAMURA, YUKI, OHTA, KINYA, MIYAZAWA, DAISUKE, SAKANASHI, MAYUKO, TAHIRA, TOMOKO, MAEDA, TOHRU, HIRAKU, YUSUKE, KAWANISHI, SHOSUKE
Format Journal Article
LanguageEnglish
Published Athens International Institute of Anticancer Research 01.10.2020
Subjects
Anthracycline
Copper
Damage assessment
Deoxyguanosine
Deoxyribonucleic acid
DNA
DNA damage
Oxidation
Oxidative stress
Plasmids
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Summary:Background/Aim: The aim of the present study was to investigate whether idarubicin (IDR) induces oxidative DNA damage in the presence of copper (II). Materials and Methods: DNA damage was evaluated by pBR322 plasmid DNA cleavage. The formation of oxidative stress markers [O2•− and 8-hydroxy-2'-deoxyguanosine (8-OHdG)] was analysed. Results: IDR induced DNA damage and O2•− and 8-OHdG generation in the presence of copper (II). Conclusion: IDR induced oxidative DNA damage in the presence of copper (II). Since it has been reported that the concentration of copper in the serum of cancer patients is higher than that in healthy groups, IDR-induced oxidative DNA damage in the presence of copper (II) may play an important role in anticancer therapeutic strategies.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.14548