Co-crystallization and small molecule crystal form diversity: from pharmaceutical to materials applications
Co-crystallization is the supramolecular phenomenon of aggregation of two or more different chemical entities in a crystalline lattice through non-covalent interactions. It encompasses the study of the manifestation of multi-component crystalline solids as well as their design. The chemistry communi...
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| Published in | CrystEngComm Vol. 18; no. 44; pp. 8528 - 8555 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
01.01.2016
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Co-crystallization is the supramolecular phenomenon of aggregation of two or more different chemical entities in a crystalline lattice through non-covalent interactions. It encompasses the study of the manifestation of multi-component crystalline solids as well as their design. The chemistry community and the literature suggest cocrystals with reference to co-crystallization products and multi-component crystalline solids. Over the last decade cocrystals have become very popular as a potential new/alternate solid form of pharmaceuticals. However, there is no consensus on what exactly a cocrystal means and what it constitutes across academia, industry and regulatory bodies. On the other hand, cocrystals have been endorsed to the extent that the following facts have been obscured: (1) cocrystals are only one of the putative outcomes of co-crystallization, if at all, and (2) their application goes way beyond pharmaceuticals. Solvates, solid solutions, eutectics, salts, ionic liquids, solid dispersions, supramolecular gelators
etc.
are among the multifarious products of co-crystallization. The manifestation of these supramolecular/non-covalent crystalline adducts is controlled by the inherent nature of the system (the components involved) besides the surroundings (temperature, solvent, pH
etc.
); in effect it is a thermodynamic outcome. Each of these adducts, including cocrystals, are unique, exhibit varied physicochemical properties and are amenable to design and therefore have, and potentially find, manifold applications in diverse fields such as organic synthesis & separation, green chemistry, energy storage, solar cells, electronics, luminescent and smart materials, apart from pharmaceuticals. This article highlights the diversity of crystal forms and the utility of small molecule supramolecular combinations.
The design, manifestation and applications of various co-crystallization products of small molecule supramolecular combinations are presented. |
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| Bibliography: | Guru Row is Dean (Sciences) and Professor at the Solid State and Structural Chemistry Unit, Indian Institute of Science, Bengaluru, India. He completed Masters from Bangalore University (1971) and PhD from the Indian Institute of Science (1976). After a post doctoral stint at Buffalo, USA, he worked as a Scientist in NCL-Pune, India, and later joined Indian Institute of Science and became a full Professor in 1998. His research interests are charge density analysis of organic and inorganic compounds, halogen bonding and other exotic interactions, polymorphism, in situ cryo-crystallography and photo-catalytic and proton conduction applications. He has authored about 450 research publications and is a recipient of J. C. Bose National Fellowship. He is serving as the Editor of Publications, Indian Academy of Sciences, and Regional Co-Chair, ICDD, USA. Ramanpreet Kaur was born in Patiala, Punjab, India, in 1988. She received her Bachelors (Chemistry Honors) from Panjab University, Chandigarh, India, in 2009. She completed her Masters (Chemistry) in 2011 and PhD (Chemistry) in 2015 from Prof. T. N. Guru Row's Research Group, Indian Institute of Science, Bengaluru, India, as an Integrated PhD student. Currently, she is working as a Post-doctoral Fellow in Prof. Adam Matzger's Research Group, University of Michigan, USA. Her research activities are in pharmaceutical solid state chemistry and material applications of organic multi-component systems. Suryanarayan Cherukuvada was born at Kakinada, Andhra Pradesh, India, in 1980. He received his Masters (Biochemistry) from Acharya Nagarjuna University in 2003 and obtained Bachelors (Education) from Andhra University in 2006. He completed PhD (Chemistry) in 2013 at Prof. Ashwini Nangia's Research Group, University of Hyderabad, as an ICMR Research Fellow. He worked as a Dr. D. S. Kothari Post Doctoral Fellow in Prof. T. N. Guru Row's Research Group, Indian Institute of Science, and currently is an independent researcher holding a Start-Up Research Grant from SERB, India. His research activities are in organic and pharmaceutical solid state chemistry. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1466-8033 1466-8033 |
| DOI: | 10.1039/c6ce01835a |