Zika Virus-Associated Cerebellitis with Complete Clinical Recovery

Zika virus (ZIKV) was first detected in the Americas in Brazil in 2015, with a rapid spread to surrounding countries. In Panama, the outbreak began in November 2015 in an indigenous community located on the Caribbean side of the country. Zika virus is typically associated with a diffuse rash, fever,...

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Published inThe American journal of tropical medicine and hygiene Vol. 99; no. 5; pp. 1318 - 1320
Main Authors Pachar, Mónica R, Araúz, Dimelza, Gundacker, Nathan D, Suárez, Marixcel, Suárez, José Antonio, Moreno, Brechla, López-Vergès, Sandra, Araúz, Ana B
Format Journal Article
LanguageEnglish
Published United States Institute of Tropical Medicine 01.01.2018
The American Society of Tropical Medicine and Hygiene
Subjects
Adult
Antibodies, Viral - blood
Ataxia - virology
Brazil
Cerebellar Diseases - diagnostic imaging
Cerebellar Diseases - therapy
Cerebellar Diseases - virology
Coinfection - diagnosis
Coinfection - virology
Dengue - diagnosis
Female
Flavivirus Infections - diagnosis
Headache - virology
Hospitalization
Humans
Polymerase Chain Reaction
RNA, Viral - genetics
Tomography, X-Ray Computed
Treatment Outcome
Vertigo - virology
Zika virus
Zika Virus - genetics
Zika Virus - isolation & purification
Zika Virus Infection - complications
Zika Virus Infection - diagnosis
Brazil
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Summary:Zika virus (ZIKV) was first detected in the Americas in Brazil in 2015, with a rapid spread to surrounding countries. In Panama, the outbreak began in November 2015 in an indigenous community located on the Caribbean side of the country. Zika virus is typically associated with a diffuse rash, fever, and conjunctivitis. It can rarely cause neurologic manifestations, most commonly microcephaly and Guillain-Barré syndrome. Encephalitis and acute encephalomyelitis are known complications, but ZIKV-associated cerebellitis has yet to be reported in the literature. Herein, we report a case of cerebellitis in a patient infected with ZIKV. This patient developed severe frontal headache and vertigo on the third day of illness, and dysarthria and ataxia on the fifth day. After 1 week of hospitalization, the patient completely recovered. The laboratory serological diagnosis was complicated because of the detection of antibodies against dengue, suggesting a secondary flavivirus infection.
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These authors contributed equally to this work.
Authors’ addresses: Mónica R. Pachar, Marixcel Suárez, and Ana B. Araúz, Hospital Santo Tomas, Infectious Diseases, Panama City, Panama, E-mails: dra.pachar@hotmail.com, marixcel@gmail.com, and anabelenarauz@gmail.com. Dimelza Araúz, Brechla Moreno, and Sandra López-Vergès, Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama, E-mails: darauz@gorgas.gob.pa, brechla@yahoo.es, and slopez@gorgas.gob.pa. José Antonio Suarez, Clinical Research Unit, Gorgas Memorial Institute of Health Studies, Panama City, Panama, E-mail: jsuarez@gorgas.gob.pa. Nathan D. Gundacker, Infectious Diseases, UAB Hospital, Birmingham, AL, E-mail: ndgundacker@gmail.com.
Financial support: This work has been carried out with management funds of HST and ICGES, as well as MEF. project 09044.051 (S. L. V.).
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.18-0261