Hydrolytic stability and biocompatibility on smooth muscle cells of polyethylene glycol–polycaprolactone-based polyurethanes

Interactions between smooth muscle cells (SMCs) and biomaterials must not result in phenotype changes as this may generate uncontrolled multiplication processes and occlusions in vascular grafts. The aim of this study was to relate the hydrolytic stability and biocompatibility of polyurethanes (PUs)...

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Bibliographic Details
Published inJournal of materials research Vol. 35; no. 23-24; pp. 3276 - 3285
Main Authors Morales-Gonzalez, Maria, Arévalo-Alquichire, Said, Diaz, Luis E., Sans, Juan Ángel, Vilariño-Feltrer, Guillermo, Gómez-Tejedor, José A., Valero, Manuel F.
Format Journal Article
LanguageEnglish
Published New York, USA Cambridge University Press 14.12.2020
Springer International Publishing
Springer Nature B.V
Subjects
Adhesion
Aorta
Applied and Technical Physics
Arteries
Biocompatibility
Biomaterials
Biomedical materials
Biomedical Materials, Regenerative Medicine and Drug Delivery
Blood vessels
Cell adhesion & migration
Contact angle
Fibroblasts
Foreign bodies
Inorganic Chemistry
Materials Engineering
Materials research
Materials Science
Mechanical properties
Modulus of elasticity
Morphology
Multiplication
Muscles
Nanotechnology
Polycaprolactone
Polyethylene glycol
Polymers
Polyurethane
Smooth muscle
Stability
Synthetic products
Tissue engineering
Toxicity
biomaterial
biomedical
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Summary:Interactions between smooth muscle cells (SMCs) and biomaterials must not result in phenotype changes as this may generate uncontrolled multiplication processes and occlusions in vascular grafts. The aim of this study was to relate the hydrolytic stability and biocompatibility of polyurethanes (PUs) on SMCs. A higher polycaprolactone (PCL) concentration was found to improve the hydrolytic stability of the material and the adhesion of SMCs. A material with 5% polyethylene glycol, 90% PCL, and 5% pentaerythritol presented high cell viability and adhesion, suggesting a contractile phenotype in SMCs depending on the morphology. Nevertheless, all PUs retained their elastic modulus over 120 days, similar to the collagen of native arteries (~10 MPa). Furthermore, aortic SMCs did not present toxicity (viability over 80%) and demonstrated adherence without any abnormal cell multiplication processes, which is ideal for the function to be fulfiled in situ in the vascular grafts.
ISSN:0884-2914
2044-5326
DOI:10.1557/jmr.2020.303