Stress‐induced plasma cortisol concentrations in infancy are associated with later parenting behaviors in female rhesus macaques (Macaca mulatta)

• Published in: Developmental psychobiology Vol. 63; no. 5; pp. 1098 - 1108
• Main Authors: Wood, Elizabeth K., Halter, Colt M., Gabrielle, Natalia, Capitanio, John P., Higley, James Dee
• Format: Journal Article
• Language: English
• Published: United States 01.07.2021
• Subjects: Adult; Animals; early risk; Female; Humans; Hydrocortisone; Macaca mulatta - physiology; Maternal Behavior - physiology; maternal sensitivity; mother‐infant relationship; Parenting; parenting style; plasma cortisol; rhesus macaque; stress reactivity; Stress, Psychological; maternal sensitivity; mother-infant relationship; rhesus macaque; stress reactivity; parenting style; plasma cortisol; early risk
• ISSN: 0012-1630; 1098-2302; 1098-2302
• DOI: 10.1002/dev.22098

Few studies have longitudinally assessed the relationship between infant stress reactivity and future parenting style. Studies show that stress‐induced plasma cortisol concentrations are stable over development and that they can be utilized as a marker for stress reactivity. This study investigates the relationship between stress‐induced plasma cortisol concentrations in infancy and later parenting behavior in a translational nonhuman primate model. We hypothesized that higher stress‐induced cortisol levels in infancy would predict impairments in maternal behaviors in adulthood. Subjects were rhesus macaque females (N = 122; Macaca mulatta), assessed as infants and again as mothers. At 3–4 months of age, subjects underwent a standardized BioBehavioral Assessment during which blood samples were obtained and they were assessed for behaviorally inhibition. Approximately 7 years later, subjects were observed as they interacted with their own offspring for four 300‐s sessions. Typical rhesus monkey mother‐offspring behaviors were recorded, including approaches and leaves and maternal cradling. Results showed that subjects' stress‐induced cortisol concentrations and whether they exhibited behavioral inhibition as infants predicted later maternal behavior, with high cortisol concentrations and behavioral inhibition predicting high rates of offspring approaches and leaves and low rates of maternal cradling. Results also showed that higher stress‐induced cortisol concentrations in infancy predicted higher scores on the Brown Index, an indication that the subjects' offspring, rather than the subject themselves, initiated changes in proximity. Taken together, these results suggest that individuals that exhibit higher stress‐induced cortisol concentrations and behavioral inhibition at 3–4 months of age are at risk for engaging in less sensitive parenting behaviors as adults. To the extent that these findings generalize to humans, they suggest an important link between stress‐induced cortisol concentrations and behavioral inhibition in infancy and behavior later in life, such that early‐life stress reactivity can serve as a marker for later parenting behavior.