Additivity of nicotinic and muscarinic cholinergic stimulation of substantia nigra

• Published in: Neuroreport Vol. 3; no. 12; p. 1105
• Main Authors: Parker, G C, Winn, P
• Format: Journal Article
• Language: English
• Published: England 01.12.1992
• Subjects: Animals; Carbachol - pharmacology; Dose-Response Relationship, Drug; Drug Synergism; Eating - drug effects; Ganglionic Stimulants - administration & dosage; Ganglionic Stimulants - pharmacology; Male; Microinjections; Nicotine - pharmacology; Parasympathetic Nervous System - drug effects; Parasympathomimetics - administration & dosage; Parasympathomimetics - pharmacology; Rats; Stimulation, Chemical; Substantia Nigra - drug effects

Microinjection of cholinergic agonists into the anterior substantia nigra increases behaviours for which there is a pre-existing tendency and a low current rate. Rats received microinjections of carbachol, nicotine or a combination of both into the anterior substantia nigra. Carbachol and nicotine b...