Additivity of nicotinic and muscarinic cholinergic stimulation of substantia nigra

Microinjection of cholinergic agonists into the anterior substantia nigra increases behaviours for which there is a pre-existing tendency and a low current rate. Rats received microinjections of carbachol, nicotine or a combination of both into the anterior substantia nigra. Carbachol and nicotine b...

Full description

Saved in:
Bibliographic Details
Published inNeuroreport Vol. 3; no. 12; p. 1105
Main Authors Parker, G C, Winn, P
Format Journal Article
LanguageEnglish
Published England 01.12.1992
Subjects
Animals
Carbachol - pharmacology
Dose-Response Relationship, Drug
Drug Synergism
Eating - drug effects
Ganglionic Stimulants - administration & dosage
Ganglionic Stimulants - pharmacology
Male
Microinjections
Nicotine - pharmacology
Parasympathetic Nervous System - drug effects
Parasympathomimetics - administration & dosage
Parasympathomimetics - pharmacology
Rats
Stimulation, Chemical
Substantia Nigra - drug effects
Online AccessGet more information

Cover

More Information
Summary:Microinjection of cholinergic agonists into the anterior substantia nigra increases behaviours for which there is a pre-existing tendency and a low current rate. Rats received microinjections of carbachol, nicotine or a combination of both into the anterior substantia nigra. Carbachol and nicotine both stimulated consumption of palatable food in a dose-dependent manner (F(3,24) = 3.99, p < 0.02 and F(3,33) = 7.07, p < 0.01 respectively). Addition of carbachol to each dose of nicotine caused a significant increase in feeding compared with nicotine alone (F(1,23) = 7.01, p < 0.015). This suggests muscarinic or nicotinic cholinergic stimulation of the anterior substantia nigra can have behaviourally similar effects and, at the doses used here, the effects of nicotinic and muscarinic stimulation are additive.
ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-199212000-00018