RU24722 induces spatially organized phenotypic plasticity in the locus coeruleus

The plasticity of tyrosine hydroxylase (TH) expression in rat locus coeruleus (LC) was evaluated after RU24722 TH induction using, as a new parameter of characterization, the quantitative topology of LC defined by TH-positive cells. This new phenotype was spatially organized into cell subpopulations...

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Bibliographic Details
Published inNeuroreport Vol. 5; no. 14; p. 1793
Main Authors Debure, L I, Bezin, L, Ginovart, N, Rousset, C, Pujol, J F, Weissmann, D
Format Journal Article
LanguageEnglish
Published England 08.09.1994
Subjects
Animals
Fenclonine - pharmacology
Locus Coeruleus - drug effects
Locus Coeruleus - enzymology
Male
Neuronal Plasticity - drug effects
Phenotype
Rats
Rats, Inbred Strains
Reserpine - pharmacology
Tyrosine 3-Monooxygenase - metabolism
Vincamine - analogs & derivatives
Vincamine - pharmacology
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Summary:The plasticity of tyrosine hydroxylase (TH) expression in rat locus coeruleus (LC) was evaluated after RU24722 TH induction using, as a new parameter of characterization, the quantitative topology of LC defined by TH-positive cells. This new phenotype was spatially organized into cell subpopulations in the medial LC, dorsal and ventro-lateral to the initial perikaryal space. Reserpine and parachlorophenylalanine, which elicited a similar increase in the TH content, failed to induce a significant change in the number of TH-expressing cells. Activation of TH expression is not sufficient to reveal the existence of such a plasticity and some original but still unknown mechanism(s) of control of TH expression is affected by RU24722.
ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-199409080-00027