Contrast‐Enhanced Transrectal Ultrasound for Follow‐up After Focal HIFU Ablation for Prostate Cancer

• Published in: Journal of ultrasound in medicine Vol. 38; no. 3; pp. 811 - 819
• Main Authors: de Castro Abreu, Andre L., Ashrafi, Akbar N., Gill, Inderbir S., Oishi, Masakatsu, Winter, Matthew W., Park, Daniel, Duddalwar, Vinay, Stern, Mariana C., Palmer, Suzanne L., Aron, Manju, Gulati, Mittul
• Format: Journal Article
• Language: English
• Published: England 01.03.2019
• Subjects: Adult; Aged; Aged, 80 and over; Contrast Media; contrast‐enhanced ultrasound; focal therapy; Follow-Up Studies; High-Intensity Focused Ultrasound Ablation; high‐intensity focused ultrasound; Humans; Image Enhancement - methods; Male; Middle Aged; Prostate - diagnostic imaging; Prostate - surgery; prostate cancer; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - surgery; transrectal ultrasound; Treatment Outcome; Ultrasonography - methods; transrectal ultrasound; prostate cancer; focal therapy; contrast-enhanced ultrasound; high-intensity focused ultrasound
• ISSN: 0278-4297; 1550-9613
• DOI: 10.1002/jum.14765

The optimal strategy for imaging after focal therapy for prostate cancer is evolving. This series is an initial report on the use of contrast‐enhanced transrectal ultrasound (TRUS) in follow‐up of patients after high‐intensity focused ultrasound (HIFU) hemiablation for prostate cancer. In 7 patients who underwent HIFU hemiablation, contrast‐enhanced TRUS findings were as follows: (1) contrast‐enhanced TRUS clearly showed the HIFU ablation defect as a sharply marginated nonenhancing zone in all patients; (2) contrast‐enhanced TRUS identified suspicious foci of recurrent enhancement within the ablation zone in 2 patients, facilitating image‐guided prostate biopsy, which showed prostate cancer; and (3) contrast‐enhanced TRUS findings correlated with multiparametric magnetic resonance imaging and biopsy histologic findings.