Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex

Slices of rat cingulate cortex, when incubated in magnesium-free medium, produce spontaneous epileptiform spikes. Here it is demonstrated that the metabotropic glutamate receptor (mGluR) agonists +/- trans-1-amino-cyclopentane-1,3-dicarboxylic acid (+/- Trans-ACPD), IS3R-ACPD and quisqualic acid (qu...

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Bibliographic Details
Published inNeuroreport Vol. 3; no. 10; p. 916
Main Author Sheardown, M J
Format Journal Article
LanguageEnglish
Published England 01.10.1992
Subjects
Animals
Anticonvulsants - pharmacology
Cerebral Cortex - drug effects
Cycloleucine - analogs & derivatives
Cycloleucine - pharmacology
Epilepsy - prevention & control
Excitatory Amino Acid Antagonists
In Vitro Techniques
Male
Quisqualic Acid - pharmacology
Rats
Rats, Wistar
Receptors, AMPA
Receptors, Glutamate - physiology
Synapses - drug effects
Synapses - metabolism
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Summary:Slices of rat cingulate cortex, when incubated in magnesium-free medium, produce spontaneous epileptiform spikes. Here it is demonstrated that the metabotropic glutamate receptor (mGluR) agonists +/- trans-1-amino-cyclopentane-1,3-dicarboxylic acid (+/- Trans-ACPD), IS3R-ACPD and quisqualic acid (quis) can reduce the frequency of these bursts in a concentration-dependent manner. The IC50 values were 16, 12 and 26 microM, respectively. The low concentrations of +/- trans- and IS3R-ACPD used, plus the lack of NMDA antagonism shown by these compounds, suggest that the effect may be via a presynaptic reduction in glutamate release. The relative potency of the agonists IS3R-ACPD > Trans-ACPD > quis would seem to suggest that the mGluR1 receptor is not involved.
ISSN:0959-4965
DOI:10.1097/00001756-199210000-00024