Does a blood pressure J curve exist for patients with chronic kidney disease?

Aggressive reduction of blood pressure may increase cardiovascular events (the J‐curve phenomenon) in certain populations. In this regard, most studies in patients with chronic kidney disease have shown a J curve for cardiovascular morbidity and mortality, and this phenomenon persists after adjustin...

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Published inThe journal of clinical hypertension (Greenwich, Conn.) Vol. 19; no. 8; pp. 764 - 770
Main Authors Robles, Nicolás Roberto, Hernandez‐Gallego, Roman, Fici, Francesco, Grassi, Guido
Format Journal Article
LanguageEnglish
Published United States John Wiley and Sons Inc 01.08.2017
Subjects
Antihypertensive Agents - therapeutic use
Blood Pressure
Blood Pressure and Clinical Outcomes
Blood Pressure Determination
chronic kidney disease
Female
Humans
hypertension
Hypertension - drug therapy
Hypertension - physiopathology
J curve
Male
Middle Aged
Renal Insufficiency, Chronic - physiopathology
Review Paper
hypertension
chronic kidney disease
J curve
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Summary:Aggressive reduction of blood pressure may increase cardiovascular events (the J‐curve phenomenon) in certain populations. In this regard, most studies in patients with chronic kidney disease have shown a J curve for cardiovascular morbidity and mortality, and this phenomenon persists after adjusting for confounding factors. Since there is no evidence that a straighter blood pressure target (<130/70 mm Hg) could improve renal outcomes, the increased cardiovascular risk associated with extreme blood pressure reduction should be seen as undesirable. Moreover, the intensive control of blood pressure may induce an unintended reduction of renal function and this decrease, in turn, may increase cardiovascular risk.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1524-6175
1751-7176
DOI:10.1111/jch.13024