A randomized double-blind study of carbamazepine in the treatment of cocaine abuse

• Published in: Clinical pharmacology and therapeutics Vol. 62; no. 1; p. 89
• Main Authors: Halikas, J A, Crosby, R D, Pearson, V L, Graves, N M
• Format: Journal Article
• Language: English
• Published: United States 01.07.1997
• Subjects: Adult; Analgesics, Non-Narcotic - administration & dosage; Analgesics, Non-Narcotic - adverse effects; Analgesics, Non-Narcotic - therapeutic use; Carbamazepine - administration & dosage; Carbamazepine - adverse effects; Carbamazepine - therapeutic use; Cocaine; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Humans; Logistic Models; Male; Patient Compliance; Substance-Related Disorders - drug therapy; Surveys and Questionnaires; Treatment Outcome
• ISSN: 0009-9236
• DOI: 10.1016/S0009-9236(97)90155-7

A 12-week, randomized, double-blind, placebo-controlled, fixed-dose outpatient study of carbamazepine (400 mg and 800 mg) in the treatment of cocaine dependence was performed. Data were analyzed with respect to both treatment condition and carbamazepine serum levels. Outcome variables included subject retention, cocaine urinalysis, self-reported cocaine use, cocaine craving, patient and clinical global impressions, the Drug Impairment Rating Scale for Cocaine, and side effects. Compared with placebo, the 400 mg treatment condition exhibited a greater decrease in the rate of positive cocaine urinalyses and a reduction in intensity and duration of craving over the course of the study. Higher serum carbamazepine levels were associated with a lower rate of positive cocaine urinalysis, fewer days of self-reported cocaine use, briefer craving episodes, and greater subject interval retention. The clinical and methodologic implications of these findings and of the study design are discussed.