"Know Diabetes by Heart": role of adipocyte-cardiomyocyte communications

Cardiovascular disease is the leading cause of morbidity in patients with diabetes mellitus. In 2019, the American Heart Association and the American Diabetes Association (along with industry leaders) launched the groundbreaking collaborative initiative "Know Diabetes by Heart™" to reduce...

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Published inMedical Review Vol. 1; no. 1; pp. 14 - 17
Main Authors Wang, Yajing, Lau, Wayne Bond, Ma, Xinliang
Format Journal Article
LanguageEnglish
Published Germany De Gruyter 01.10.2021
Subjects
adipocyte
cardiomyocyte
diabetes
myocardial ischemia
myocardial ischemia
diabetes
adipocyte
cardiomyocyte
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Summary:Cardiovascular disease is the leading cause of morbidity in patients with diabetes mellitus. In 2019, the American Heart Association and the American Diabetes Association (along with industry leaders) launched the groundbreaking collaborative initiative "Know Diabetes by Heart™" to reduce cardiovascular deaths in type 2 diabetic patients. The molecular basis linking diabetes with cardiovascular complications has not yet been fully defined. Recent clinical and experimental studies strongly suggest that adipocyte dysfunction and subsequent pathological communications between adipocyte and cardiomyocytes play important roles in diabetic cardiac injury. This perspective article will review recent development concerning adipocyte-cardiomyocyte communications, and identify the most critical questions remain to be answered in this filed.
Bibliography:ObjectType-Article-1
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ISSN:2749-9642
2097-0773
2749-9642
DOI:10.1515/mr-2021-0008