Long-term alterations in growth factor mRNA expression following seizures

Although alterations in growth factor mRNA occur during neuronal insults, little is known about the long-term effects of neuronal insults on growth factor expression. We have examined the effects of prolonged post-ictal times on the expression of Brain-derivered nerve factor (BDNF) and Neurotrophin...

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Bibliographic Details
Published inNeuroreport Vol. 8; no. 6; p. 1445
Main Authors Garcia, M L, Garcia, V B, Isackson, P J, Windebank, A J
Format Journal Article
LanguageEnglish
Published England 14.04.1997
Subjects
Animals
Brain-Derived Neurotrophic Factor - biosynthesis
Growth Hormone - genetics
Hippocampus - metabolism
Male
Nerve Growth Factors - biosynthesis
Neurotrophin 3
Rats
Rats, Sprague-Dawley
RNA, Messenger - biosynthesis
Seizures - metabolism
Time Factors
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Summary:Although alterations in growth factor mRNA occur during neuronal insults, little is known about the long-term effects of neuronal insults on growth factor expression. We have examined the effects of prolonged post-ictal times on the expression of Brain-derivered nerve factor (BDNF) and Neurotrophin 3 (NT3) following Kainic acid (KA)-induced seizures. In situ hybridization was performed on male Sprague-Dawley rats sacrificed 1-2 weeks following intracranial ventricular KA injections. BDNF mRNA increased bilaterally 1 and 2 weeks after injections, whereas NT3 mRNA decreased contralaterally 1 week and bilaterally 2 weeks post-injection. These observations provide evidence that alterations in growth factor mRNA expression occur even after prolonged post-ictal recovery suggesting a possible role for growth factors in recovery and continued maintenance of surviving neurons within limbic seizure foci.
ISSN:0959-4965
DOI:10.1097/00001756-199704140-00024