19F MRI for quantitative in vivo cell tracking

Cellular therapy, including stem cell transplants and dendritic cell vaccines, is typically monitored for dosage optimization, accurate delivery, and localization using noninvasive imaging, of which magnetic resonance imaging (MRI) is a key modality. 19F MRI retains the advantages of MRI as an imagi...

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Bibliographic Details
Published inTrends in biotechnology (Regular ed.) Vol. 28; no. 7; pp. 363 - 370
Main Authors Srinivas, Mangala, Heerschap, Arend, Ahrens, Eric T., Figdor, Carl G., Vries, I. Jolanda M. de
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.07.2010
Elsevier Limited
Subjects
Biocompatibility
Biomedical materials
Blood substitutes
Cellular
Contrast agents
Fluorides
Imaging
In vivo testing
In vivo tests
Medical imaging
NMR
Nuclear magnetic resonance
Perfluorocarbons
Stem cells
Studies
Surgical implants
Technological change
Toxicity
Tracking
Ultrasonic imaging
Vaccines
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Summary:Cellular therapy, including stem cell transplants and dendritic cell vaccines, is typically monitored for dosage optimization, accurate delivery, and localization using noninvasive imaging, of which magnetic resonance imaging (MRI) is a key modality. 19F MRI retains the advantages of MRI as an imaging modality, and also allows direct detection of labeled cells for unambiguous identification and quantification, unlike typical metal-based contrast agents. Recent developments in 19F MRI-based in vivo cell quantification, the existing clinical use of 19F compounds and current explosive interest in cellular therapeutics have brought 19F imaging technology closer to clinical application. We review the application of 19F MRI to cell tracking, discussing intracellular 19F labels, cell labeling and in vivo quantification, as well as the potential clinical uses of 19F MRI.
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ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2010.04.002