Localization of mRNA for the apoptosis-linked gene ALG-2 in young and aged rat brain

ALG-2 is a recently described pro-apoptosis gene that codes for a Ca2+-binding protein involved in T-cell receptor-, Fas- and glucocorticoid-induced cell death. We have used in situ hybridization histochemistry to examine the regional distribution of ALG-2 mRNA in the brain of 3- and 24-month old ra...

Full description

Saved in:
Bibliographic Details
Published inNeuroreport Vol. 9; no. 9; p. 1981
Main Authors Venn, M K, Conway, E L
Format Journal Article
LanguageEnglish
Published England 22.06.1998
Subjects
Aging - genetics
Aging - metabolism
Animals
Apoptosis - physiology
Brain Chemistry - genetics
Genes - physiology
In Situ Hybridization
Male
Nerve Degeneration - pathology
Rats
Rats, Wistar
RNA Probes
RNA, Messenger - biosynthesis
Online AccessGet more information

Cover

More Information
Summary:ALG-2 is a recently described pro-apoptosis gene that codes for a Ca2+-binding protein involved in T-cell receptor-, Fas- and glucocorticoid-induced cell death. We have used in situ hybridization histochemistry to examine the regional distribution of ALG-2 mRNA in the brain of 3- and 24-month old rats. There was widespread, predominantly neuronal distribution of ALG-2 mRNA throughout the brain. Areas expressing high levels included the granule and pyramidal cell layers of the hippocampus, choroid plexus, area postrema, and a number of hindbrain nuclei. ALG-2 mRNA levels in aged rats were not significantly different to young animals. The pattern of expression of ALG-2 mRNA in adult brain is similar to other apoptosis-related genes and suggests it may be involved in neuronal survival.
ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-199806220-00012