Haemodialysis for lithium poisoning: Translating EXTRIP recommendations into practical guidelines

• Published in: British journal of clinical pharmacology Vol. 86; no. 5; pp. 999 - 1006
• Main Authors: Buckley, Nicholas A., Cheng, Sonia, Isoardi, Katherine, Chiew, Angela L., Siu, William, Vecellio, Elia, Chan, Betty S.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.05.2020
• Subjects: acute on chronic lithium poisoning; chronic lithium toxicity; EXTRIP; haemodialysis; nomogram; Original; haemodialysis; acute on chronic lithium poisoning; chronic lithium toxicity; nomogram; EXTRIP
• ISSN: 0306-5251; 1365-2125
• DOI: 10.1111/bcp.14212

Objectives This study aimed to determine the impact on practice of applying the Extracorporeal Treatments in Poisoning (EXTRIP) Workgroup criteria to lithium toxicity. Method We retrospectively examined the medical records of patients from three hospitals who presented with chronic or acute on chronic lithium poisoning with a lithium concentration ≥1.3 mmol/L (2008‐2018). We determined which criteria were met by patients and their subsequent course. We developed and validated a method to predict if lithium concentration would be >1mmol/L at 36 hours. Results There were 111 acute on chronic and 250 chronic lithium toxic patients. Nine patients (2.5%) were treated with haemodialysis. Six chronic patients had neurological sequelae. The “estimated lithium concentration at 36 hours > 1 mmol/L” criterion required pharmacokinetic calculations. A simple nomogram was developed using Estimated Glomerular Filtration Rate (eGFR) and lithium concentration. For chronic toxicity, the nomogram would have correctly predicted lithium concentration >1.4 mmol/L at 36 hours in all except two patients. If EXTRIP criteria were followed, dialysis would have been instituted for 211 patients (58%). However, only 51 patients with chronic toxicity fulfilled both a concentration and a clinical criterion. Late neurological sequelae were observed in five out of six patients who fulfilled a concentration and a clinical criterion on admission, with the sixth meeting these criteria shortly after admission. Conclusions The EXTRIP criteria are too broad, but minor modifications allow haemodialysis to be targeted to those most at risk of sequelae. Most acute on chronic poisonings do not need haemodialysis, but it might shorten hospital stay in those with very high concentrations. The nomogram accurately predicts the fall in lithium concentration for chronic poisoning.