Role of thymic B cells in the development of thymus-derived regulatory T cell in vitro
Highlights • Thymic B cells in the condition of our experiments did not influence the generation of nTregs, but rather maintain their viability when activated by both activators. • Activated thymic B cells maintained the high percentage of nTreg generation or counteracted the decrease of this percen...
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Published in | Immunology letters Vol. 185; pp. 56 - 63 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.05.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Thymic B cells in the condition of our experiments did not influence the generation of nTregs, but rather maintain their viability when activated by both activators. • Activated thymic B cells maintained the high percentage of nTreg generation or counteracted the decrease of this percentage observed in non-activated culture. • Both activators (LPS and IMQ) have the same effect in the process of nTreg generation by B cells. • The percentage of B cells was strongly increased in the conditions of our experiments\72 h in LPS and IMQ-supplemented medium. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0165-2478 1879-0542 |
DOI: | 10.1016/j.imlet.2017.03.007 |