Extracellular Matrices for Bone Regeneration: A Literature Review

• Published in: Tissue engineering. Part A Vol. 23; no. 23-24; pp. 1436 - 1451
• Main Authors: Mansour, Alaa, Mezour, Mohamed Amine, Badran, Zahi, Tamimi, Faleh
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.12.2017; Mary Ann Liebert
• Subjects: Allografts; Angiogenesis; Animals; Autografts; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Biomedical materials; Bone and Bones - cytology; Bone and Bones - metabolism; Bone biomaterials; Bone composition; Bone grafts; Bone growth; Bone Regeneration - drug effects; Bone surgery; Cartilage; Cell division; Chondrocytes; Collagen; Defects; Extracellular matrix; Extracellular Matrix - chemistry; Geriatry and gerontology; Glycosaminoglycans; Growth factors; Human health and pathology; Humans; Hydrogels; Hydroxyapatite; Life Sciences; Ligands; Literature reviews; Long bone; Mesenchyme; Osteoblasts; Peptides; Proteins; Regeneration; Rhumatology and musculoskeletal system; Self-assembly; Skin & tissue grafts; Special Focus Articles; Stem cells; Tissue engineering; Tissue Engineering - methods; Trace elements; Canada; Montreal Quebec Canada; bone regeneration; extracellular matrix; decellularization

The gold standard material for bone regeneration is still autologous bone, a mesenchymal tissue that consists mainly of extracellular matrix (ECM) (90% v/v) and little cellular content (10% v/v). However, the fact that decellularized allogenic bone grafts often present a clinical performance compara...