Fly models of Huntington's disease

Can Drosophila models be engineered that accurately reflect Huntington's disease (HD) and other neurological diseases and can they contribute to the search for treatments and cures? A number of publications seem to provide a resounding yes to that question. Here we seek to review some of the sa...

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Bibliographic Details
Published inHuman molecular genetics Vol. 12; no. suppl-2; pp. R187 - R193
Main Authors Marsh, J. Lawrence, Pallos, Judit, Thompson, Leslie M.
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 15.10.2003
Oxford Publishing Limited (England)
Subjects
Animals
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
Disease Models, Animal
Drosophila
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Huntington Disease - metabolism
Huntington Disease - physiopathology
Human
Animal model
Treatment
Arthropoda
Insecta
Drosophila
Huntington disease
Invertebrata
Neurological disorder
Diptera
Drosophilidae
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Summary:Can Drosophila models be engineered that accurately reflect Huntington's disease (HD) and other neurological diseases and can they contribute to the search for treatments and cures? A number of publications seem to provide a resounding yes to that question. Here we seek to review some of the salient features of these models.
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ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/ddg271