Nasobiliary drainage induces long-lasting remission in benign recurrent intrahepatic cholestasis

• Published in: Hepatology (Baltimore, Md.) Vol. 43; no. 1; pp. 51 - 53
• Main Authors: STAPELBROEK, Janneke M, VAN ERPECUM, Karel J, KLOMP, Leo W. J, VENNEMAN, Niels G, SCHWARTZ, Thijs P, VAN BERGE HENEGOUWEN, Gerard P, DEVLIN, John, VAN NIEUWKERK, Carin M. J, KNISELY, A. S, HOUWEN, Roderick H. J
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley 01.01.2006
• Subjects: Adult; Bile - chemistry; Bile Acids and Salts - analysis; Biological and medical sciences; Cholestasis, Intrahepatic - therapy; Drainage - methods; Endoscopy; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Nose; Other diseases. Semiology; Phospholipids - analysis; Recurrence; Intrahepatic cholostasis; Relapse; Treatment; Bypass; Surgery; Gastroenterology; Digestive diseases; Hepatic disease; Remission; Biliary tract disease; Long lasting
• ISSN: 0270-9139; 1527-3350
• DOI: 10.1002/hep.20998

Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodic cholestasis and pruritus without anatomical obstruction. Effective medical treatment is not available. We report complete and long-lasting disappearance of pruritus and normalization of serum bile salt concentrations in cholestatic BRIC patients within 24 hours after endoscopic nasobiliary drainage (NBD). Relative amounts of phospholipids and bile salts in bile collected during NBD appeared to be normal, but phospholipids other than phosphatidylcholine (especially sphingomyelin) were increased. In conclusion, we propose that temporary endoscopic nasobiliary drainage should be considered in cholestatic BRIC patients.