Gonarthritis photodynamic therapy with chlorin e6 derivatives

Highlights • Maximum concentration of a Ce6 in synovium is registered 2.5 h after injection. • Fluorescent diagnostics can be used at gonarthritis before, during and after PDT. • Optimal radiation energy density (150 J/cm2 ) was determined. • Chlorin series PS is promising and can be used to treat g...

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Published inPhotodiagnosis and photodynamic therapy Vol. 15; pp. 88 - 93
Main Authors Zharova, T.A, Ivannikov, S.V, Tonenkov, A.M, Stranadko, E. Ph, Semenova, L.A, Smorchkov, M.M, Makarov, V.I, Romanishkin, I.D, Ryabova, A.V, Loschenov, V.B
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.2016
Subjects
Animals
Chlorin e6
Diagnostics
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Fluorescent
Gonarthritis
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Light
Male
Osteoarthritis - drug therapy
Osteoarthritis - metabolism
Osteoarthritis - pathology
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - administration & dosage
Porphyrins - administration & dosage
Porphyrins - pharmacokinetics
Rabbits
Tissue Distribution
Treatment Outcome
Chlorin e6
Fluorescent
Photodynamic therapy
Diagnostics
Gonarthritis
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Summary:Highlights • Maximum concentration of a Ce6 in synovium is registered 2.5 h after injection. • Fluorescent diagnostics can be used at gonarthritis before, during and after PDT. • Optimal radiation energy density (150 J/cm2 ) was determined. • Chlorin series PS is promising and can be used to treat gonarthritis in clinics.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2016.06.002